Synthesis of biotinylated tumor-associated carbohydrate antigens for immunological studies
نویسندگان
چکیده
منابع مشابه
Tumor Associated Carbohydrate Antigens in Targeted Therapy
Tumor associated carbohydrate antigens (TACAs) are a class of glycans with important structural and signaling functions playing a major role in cell proliferation, differentiation, and apoptosis relevant to oncology. Tumor cells expressing TACAs influence prognosis and survival of cancer patients. Careful consideration must be given to structural aspects during rational design of small molecule...
متن کاملChemo-immunological Studies on Conjugated Carbohydrate-proteins Ii. Immunological Specificity of Synthetic Sugar-protein Antigens
The function of carbohydrates as determinative substances in bacterial specificity is well illustrated in the immunological differentiation of thespecific types of pneumococci and of Friedlander bacilli. Previous studies have demonstrated that the presence of type-specific polysaccharides in these encapsulated organisms determines the antigenic properties of the cell and the serological relatio...
متن کاملImmunological and Electrophoretic Studies of Human Tissue and Tumor Antigens*
Previous immunological studies (3, 4) have shown that the injection of human tumors or tis sues into rabbits results in the formation of anti bodies against only a few of the many tissue antigens. Similar observations have been made in regard to serum proteins, i.e., little antibody is produced against some serum proteins when they are in jected together with other serum proteins (1), and compa...
متن کاملImmunological and electrophoretic studies of human tissue and tumor antigens.
Previous immunological studies (3, 4) have shown that the injection of human tumors or tis sues into rabbits results in the formation of anti bodies against only a few of the many tissue antigens. Similar observations have been made in regard to serum proteins, i.e., little antibody is produced against some serum proteins when they are in jected together with other serum proteins (1), and compa...
متن کاملChemo-immunological Studies on Conjugated Carbohydrate-proteins
1. Type-specific antipneumococcus immunity has been induced in rabbits by immunization with antigen prepared by combining a specific derivative of the capsular polysaccharide of Type III Pneumococcus with globulin from horse serum. 2. Rabbits immunized with this antigen acquire active immunity against infection with virulent Type III pneumococci. 3. The sera of the immune rabbits contain type-s...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2009
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.11.113